Excerpt from: Foods and Phytonutrients that may benefit T-cells. (document)
Nucleotides are not considered an essential nutrient but they are complex molecules which take fourteen chemical steps for our body to make from simpler chemicals.
Nrf2 plays a role in the production of nucleotides.
- “Thus, NRF2 supports both NADPH and nucleotide production.” NRF2 Rewires Cellular Metabolism to Support the Antioxidant Response, (Lin et al. 2016)
- Nrf2: More information about Nrf2 and more food and recipe ideas are included in G10. Nrf2 Promoting Foods webpage / document.
Nucleotides are the building blocks of DNA and RNA. DNA is a double helix or spiral, shaped like a zipper or ladder that is coiled like a long metal spring. RNA is half of the zipper, one pole of the ladder with half of each step. Each half step would be one nucleotide.
In order for our cells to make new proteins from the DNA recipe, the encoded pattern of amino acids that will form the new protein, first a matching strand of RNA has to be produced, using many nucleotides. That is a lot of nucleotides to make before we even get started on making a new protein.
To shorten up the long chemical story - we also get some nucleotides in our diet and those are absorbed intact and can be used without the fourteen steps we would need to make our own. Different foods might provide RNA and would be good sources of varied nucleotides. Supplements are available with a more specific balance found to affect health in more directed ways such as helping with weight loss, diabetes, or for promoting recovery after surgical stress.
The balance of nucleotides available would be a limiting factor as to which genes could be activated, a chronic shortage may be affecting blood sugar or appetite. Infants born small for gestational age, low birth weight or with slow growth also may benefit from other types of nucleotides. Improved growth and reduced diarrhea was found in two different studies. (Brunser 1994 Cosgrove 1996). (p 14, Yasko 16)
Lack of nucleotides in the diet was found to cause breakdown of mucosal integrity. The mucosal lining protects our digestive system and lungs from pathogens and is needed for our other organs to function well. It is like mortar between our cells and a coat of paint along the outer surface - sealing out microbes or dust in our lungs or acidity in the stomach.
We are watery on the inside but stabilized by fibers and proteins so that the mucous layer is a moist environment but semi-solid like a gelatin dessert or fruit jelly. RNA and DNA are somewhat ladder like, or thread like, which would add to the structural matrix of the mucous lining.
- “During conditions of stress, infection, injury and trauma the demand for nucleotides is increased, in part due to the needs of the immune system. The ability of the body to produce its own nucleotides is insufficient for demand, thus necessitating support with nucleotides. In the absence of adequate nucleotides in the diet resulted in impaired mucosal integrity and function that could be reversed by supplementation with nucleotides.” (Suchner, 2000) (17)
More information about Nrf2 and more food and recipe ideas are included in G10. Nrf2 Promoting Foods webpage / document.