Zinc supplementation may help increase T-cell type of immune reaction and reduce NF-kappaB inflammatory activity.
- "Fortuitously, for reasons that remain unclear, zinc supplementation tends to boost stimulated NF-kappaB activity in lymphocytes; this effect tends to aid the activation of T lymphocytes and support cell-mediated immunity [174,175]. This likely explains why zinc supplementation can reduce the incidence of infections in the elderly [171]. Zinc thus manages to accomplish the needed trick of supporting antigen-specific immunity while curbing inflammation." (McCarty et al, 2021)
More zinc may be needed than the current nutrition guidelines for optimal health, particularly as we age. The thymus gland needs zinc to help make antibodies and mature T-cells. Extra zinc supplementation has been found to improve age related loss of thymus gland function in animal based research. (Haase et al 2009)
Zinc is also needed by beneficial intestinal microbes.
Zinc supplementation or a zinc rich diet is also benefiting our intestinal microbiome. Beneficial bacterial species need zinc in their diet too. When low zinc is available less beneficial species that don't need zinc thrive instead. (Tako, IECN2020)